The Whites went into the international still searching for their first league victory of the season, after being held to a 1-1 draw with Burnley, and they'll be eager to get the ball rolling with a big win over the Reds.
When the two sides last faced each other, back in April, Marcelo Bielsa's side held Liverpool to a 1-1 draw, with defender Diego Llorente scoring a dramatic late equaliser.
Meanwhile, as the international break draws to a close, Leeds' U23 side are in Premier League Cup action this evening against Wigan Athletic.
Discussing the difficulties of selecting a side when a number of the players are on youth international duty, head coach Mark Jackson said: “It was always planned (the team selection). We can test some of the Under-18s going into that and see how they're shaping up. A few of the 18s coaches can get a feel for how we work as well, so it's all planned out.
“When we're missing that amount of players [due to international call ups], it gives us time for the lads to kind of work individually and we can do that with some players.
“We can work on areas where they need to get better, work on areas they're good at already and use individualised programs so players can have that time to develop.”
Take a look at the latest news round-up from the Premier League, as the build-up to the weekend's action continues:
1. Spurs urged to seal swap deal
Football pundit Noel Whelan has urged Spurs to consider a swap deal with AC Milan, that would see Tanguy Ndombele head to the San Siro and Franck Kessie move the other way. Ndombele was said to be keen on leaving Spurs in the summer, but failed to secure his exit. (Football Insider) Photo: Marco Luzzani
2. Wolves target set to leave in January
Wolves target Duje Caleta-Car looks set to be sold by Marseille in January. He's believed to have snubbed both Wolves and Valencia in the last transfer window, but the Ligue 1 side are still keen to move on the Croatia international. (L'Equipe) Photo: LAURENCE GRIFFITHS
3. Magpies saw defender bid knocked back
Newcastle United reportedly had a bid in the region of £12m reject for Marseille defender Boubacar Kamara over the summer. The report also claims the France U21 international wasn't keen on making a move to St James' Park. (L'Equipe) Photo: CHRISTOPHE SIMON
4. Villa ready January raid for McKennie
Aston Villa have been tipped to make a January swoop for Juventus midfielder Weston McKennie, but they could face competition from fellow Premier League side Spurs. The former Schalke sensation is likely to cost around £25m. (Calciomercato) Photo: PAU BARRENA
5. Duo linked with Pedri
Liverpool and Manchester City have been named as two leading candidates to sign Barcelona sensation Pedri in the summer. The midfield ace, who lit up Euro 2020 with Spain, could be sold for a fee in the region of £85m. (Sport Witness) Photo: JOSEP LAGO
6. Man Utd bring in Covid-19 spot checks
Manchester United have confirmed they will become the latest club to introduce Covid-19 spot checks at home games, with the system set to become mandatory at the start of next month. Brighton, Chelsea and Spurs already have Covid-19 vaccination checks in place. (BBC Sport) Photo: Michael Regan